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TECHNOLOGICAL WATCH

Type of information: TECHNICAL ARTICLES

In this section, you can access to the latest technical information related to the PISA project topic.

Multi-target 1,4-Dihydropyridines Showing Calcium Channel Blockade and Antioxidant Capacity for Alzheimer?s Disease Therapy

In this work we describe the synthesis, Ca+2 channel blockade capacity and antioxidant power of N3,N5-bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxamides 1-9, a number of multi-target small 1,4-dihydropyridines (DHP), designed by juxtaposition of melatonin and nimodipine. As a result, we have identified antioxidant DHP 7 (Ca2+ channel blockade: 55%, and 8.78 Trolox/Equivalents), the most balanced DHP analyzed here, for potential Alzheimer?s disease therapy.

» Author: Rim Malek, Maciej Maj, Artur Wnorowski, Krzysztof J??wiak, Helene Martin, Isabel Iriepa, Ignacio Moraleda, Fakher Chabchoub, Jos? Marco-Contelles, Lhassane Ismaili

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